Sen. Edward Kennedy's diagnosis of a malignant brain tumor has left Congress without its best dealmaker and boldest liberal, a politician known for his staunch positions and willingness to work with right-wing lawmakers.

The Senate opened debate on paying for another year of the Iraq war without the Massachusetts Democrat's customary roar of outrage. Just as evident was his absence when President Bush on Wednesday signed a measure that Kennedy forged with Republicans to protect people from losing their jobs or health insurance because their genes say they are prone to future illness.

Whenever there was a deal to be made on important legislation, the scion of the famed political family was somewhere nearby despite his reputation as one of the Senate's last liberal lions.

That willingness to buck his own party and cut deals means that Kennedy has left his mark on health care, civil rights, welfare, housing, education, foreign affairs and other issues.

"He has crossed the aisle and sponsored so many legislative enactments," said Sen. Arlen Specter, R-Pa.

Conservative Sen. Pat Roberts, R-Kan., added: "Although it is no surprise there are areas where we have a difference of opinion, there are also many areas where we worked together, particularly on child-care and disability issues."

In a climate that values party loyalty and making political points more than making laws, there is a dearth of potential stand-ins.

Sen. John McCain, the likely GOP presidential nominee, is perhaps the closest. But his alliances with Democrats on campaign finance, immigration, torture and other issues has tested the patience of his party's conservative base.

House Speaker Nancy Pelosi, D-Calif., reached out and negotiated a $168 billion plan of tax rebates and other measure with Bush this year. Rep. Barney Frank, D-Mass., has put together bipartisan coalitions for advancing measures to save hundreds of thousands of strapped homeowners from foreclosures and secure civil rights for homosexuals.

Republican Sen. Lindsay Graham of South Carolina has cut deals with Democrats on getting conservative judges confirmed, banning torture in interrogating suspected terrorists, getting tougher with China on trade and expanding health care for members of the National Guard and Reserves.

But none has the reputation and record that Kennedy has in assembling coalitions and keeping them together.

In 1973, after the Watergate scandal, Kennedy co-sponsored the first bipartisan campaign finance bill. It established new contribution limits and a public financing provision for presidential elections.

Kennedy was instrumental in enacting the Americans with Disabilities Act of 1990, the State Children's Health Insurance Program and many health care initiatives.

He was an important backer of Title IX, a 1972 amendment requiring colleges and universities to provide equal funding for men's and women's athletics.

He has championed minimum-wage increases, pushing the most recent effort to raise it from $5.15 to $7.25 per hour by 2009.

Standing at his side for many of his legislative accomplishments is usually a Republican with whom Kennedy has worked to get results.

"I have held that view because he remains the single most effective member of the Senate if you want to get results," McCain said. Continued...